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FIGURE 1 5 Summary and outlook An increasing number of studies have confirmed that MOTS-c plays a vital role in bone metabolism and is instrumental in stimulating osteoblast proliferation, differentiation, and mineralization and inhibiting osteoblast apoptosis

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Use of institutional data warehouses, contributing 85% of cases, helped limit recall bias, though biological markers, including glycaemic indices, were unavailable, restricting mechanistic insight